TITLE(s): Low-Density Lipoprotein Cholesterol Bulk Is the Pivotal
Determinant of Atherosclerosis in Familial
Hypercholesterolemia.
Summary: The low-density lipoprotein (LDL) cholesterol level and
duration of exposure to the elevated LDL cholesterol level
or "LDL bulk" are the privotal determinants of
atherosclerosis and are the strongest predictors of carotid
intima-media thickness in subjects with familial
hypercholesterolemia. Other biochemical risk factors such
as fibrinogen, lipoprotein(a), homocysteine, insulin, and
plasma 8-isoprotstane, as well as LDL particle size are of
little added predictive value.
AUTHOR(s): Raal, Frederick J.
Pilcher, Gillian J.
Ja=ofe, Barry I.
In: The American Journal of Cardiology.
MAY 01 1999 v 83 n 9
Page: 1330
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TITLE(s): Factors Underlying the Increase in Carotid Intima-Media
Thickness in Borderline Hypertensives.
AUTHOR(s): Pauletto, P.
Palatini, P.
Pessina, A.C.
In: Arteriosclerosis, thrombosis, and vascular biolo
MAY 01 1999 v 19 n 5
Page: 1231
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